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Dr Keri Carpenter

Departments and Institutes

Clinical Neurosciences:

Research Interests

We explore the pathophysiology of acute brain injury and its therapy, including radiological studies and advanced bedside monitoring (transcranial Doppler, microdialysis, near-infrared spectroscopy, brain tissue oxygen) and explore mechanisms of coma and recovery. There are extensive programmes of research into hydrocephalus, haemorrhagic stroke and mathematical modelling of intracranial dynamic.

Brain injury is a major cause of disability and death. While some brain injury survivors have good outcomes, others experience varying degrees of disability, which are often life-long, with consequent demands on carers and resources. After the initial event, a complex series of biochemical and biological changes occurs in the hours and days that follow. Brain chemistry is monitored in severely injured patients by means of inserting fine semi-permeable tubes into the brain, a technique called microdialysis. The fluid collected by microdialysis is analysed in various ways. This can reveal information on energy status, metabolism and inflammation in the injured brain.

Other Publications

A full list of publications can be found here.