skip to primary navigationskip to content
 

Timothy O'Leary

Biological sensors and feedback mechanisms for controlling neural activity

Nervous systems often comprise many millions of neurons that are intricately connected and electrically excitable. Connectivity and excitability support many aspects of nervous system function. Somehow, networks of neurons self organise and maintain activity levels in a functional range during development and throughout an animal's lifetime. Dense interconnectivity and highly nonlinear, excitable neural dynamics mean that this is not a trivial problem to solve. I will show experimental evidence for voltage-gated ion channel dependent sensors of long-term neuronal activation that allow neurons to tune their excitability by regulating ion channel expression. Simple models show that a surprisingly crude activity sensor can maintain neural properties by coordinating multiple nonlinear, voltage-dependent membrane conductances.

 

 

Timothy O'Leary

Cambridge Neuroscience
Department of Engineering

University of Cambridge

Dr O'Leary received his PhD from the University of Edinburgh in 2009, switching fields from pure mathematics to neurophysiology. He has since worked on many aspects of neural physiology as an experimentalist and as a theorist. Before coming to Cambridge he worked with Eve Marder in Brandeis University, where he was a Sloan Swartz Computational Neuroscience Fellow and recipient of the 2014 Gruber International Prize from the Society for Neuroscience. He joined the Engineering Department in January 2016 as part of a mission to unite control engineers and neuroscientists.

RSS Feed News

Cambridge Network Job Fair

Apr 23, 2018

This Job Fair brings together hundreds of live vacancies, talented candidates, CV workshops, expert recruiters and businesses across all sectors, together at one venue. 4 May 2018, 12-4pm, The Postdoc Centre at Eddington

Biomaker Challenge 2018

Apr 19, 2018

Applications now open for the 2018 Biomaker Challenge! Whether you're a previous participant interested in continuing your project or curious to get involved for the first time, we're keen to hear from you!

Sensor CDT Student Tiesheng Wang wins one of the 2018 CSAR PhD Student Awards

Apr 06, 2018

The Cambridge Society for the Application of Research (CSAR) recently announced the names of the 10 PhD students from the University of Cambridge who have received the 2018 CSAR PhD Student Awards for Applied Research.

Sensor CDT student Tiesheng Wang weaves new material for energy storage

Mar 22, 2018

Sensor CDT student Tiesheng Wang and his supervisor Stoyan Smoukov have developed a new supercapacitor made from a "candy cane" like flexible polymer material composite. Its flexibility and higher charge holding properties could enable new sensor applications, such as implantable sensors.

Addressing civil engineering challenges

Feb 01, 2018

Sensor CDT students teamed up with students and staff from the Centre for Smart Infrastructure and Construction to think collectively about sensor solutions to challenges in the built environment.

View all news