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PhD studentship - Understanding of the impact of manufacturing processes on the physical and chemical stability of synthetic peptides

medimmune

In collaboration with MedImmune, the EPSRC Centre for Doctoral Training in Sensor Technologies and Applications is inviting applications for a fully funded 1+3 years MRes + PhD studentship commencing in October 2017.

The 4-year PhD studentship is available at the University of Cambridge working with Dr Sophie Jackson in the Department of Chemistry. The student will be enrolled in the Sensor CDT which has a yearly intake of around ten students. The first year involves a highly interdisciplinary programme consisting of lectures, practicals and research projects covering a wide range of technologies and applications in sensing and imaging. Successful completion of the first year will lead to a Master of Research qualification (MRes) and optimal preparation for the PhD phase in years 2-4.

The aim of this research project is to characterise chemical and organic impurities arising during the manufacture of biological therapeutic drugs under different process conditions exploring the relationship between these impurities and the physical stability of the peptide. A major objective will be to gain a better understanding of the mechanisms underlying gel and fibril formation of peptide therapeutics and how this relates to the different processing conditions. We will aim to identify predictors of early fibril formation and physical instability in the formulated peptide drug.  The project will involve many biophysical techniques including mass spectrometry, fluorescence-based methods, kinetic assays, atomic force microscopy amongst many others. There will also be some (but not extensive) peptide synthesis.

Applicants should have a First Class or a high 2:1 degree in a relevant discipline such as chemistry, biochemistry, biophysics or any related subject.

For informal enquiries please contact Dr Sophie Jackson ().

To apply for this studentship visit: http://cdt.sensors.cam.ac.uk/how-to-apply.

Please note that, due to funding restrictions, this studentship is only available to UK and EU applicants.

The deadline for applications is 5pm on Monday, 6 March 2017.

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